Quick answer: Wegovy should be injected once weekly into the abdomen, thigh or upper arm, avoiding the navel area and rotating sites each week for comfort, safety, and consistent absorption.
Wegovy has transformed weight‑management treatment across the UK and indeed many other parts of the world, particularly for adults living with obesity or those struggling with excess weight alongside related health conditions. Conditions such as cardiovascular disease, type 2 diabetes, and respiratory conditions are relevant to people choosing this treatment direction. While lifestyle changes remain at the core of any weight‑loss journey, Wegovy offers powerful additional support by helping people regulate appetite, manage hunger and stay on track long‑term. But to get the best possible results, it’s essential to understand how to use your pen correctly, and that starts with learning where and how to inject it safely.
We’ve put together this comprehensive guide that expands on every detail you need to feel fully confident with your weekly injection. We’ll walk through the basic science behind Wegovy, explain injection sites in depth, help you choose the best area for your body, and even provide a detailed step‑by‑step method designed for beginners and experienced users alike. If you’ve ever felt unsure or worried about doing something “wrong,” this expanded resource will help you feel completely in control.
What is a Wegovy injection?
Wegovy (semaglutide) is a once‑weekly injectable weight‑loss medication approved in the UK for adults with obesity or those who are overweight with weight‑related conditions such as high blood pressure, pre‑diabetes, or high cholesterol. It’s actually made using the same active ingredient as Ozempic, which is a very similar drug. However, Wegovy is prescribed for weight loss and obesity management, whereas Ozempic is approved for treating type 2 diabetes.
It works by mimicking a natural hormone called GLP‑1, which helps regulate appetite, slow digestion, and reduce cravings throughout the day. Many people report feeling full sooner and experiencing fewer urges to snack between meals, leading to significant weight loss in most users.
Wegovy comes in a pre‑filled, single‑use pen designed to make injections simple, discreet, and quick, typically taking less than 30 seconds once you get used to it. The fixed‑dose pens mean there’s nothing to measure or draw up, making them ideal for beginners and people with little to no medical aptitude.
Why injection placement is essential
Ensuring you inject Wegovy into the correct area of your body is more important than most people realise. Since Wegovy is a subcutaneous injection, meaning it needs to be delivered into the soft fat layer just beneath the skin, the injection site directly affects how well your body absorbs the medication.
Correct placement helps:
- Maintain consistent absorption each week
- Reduce the risk of irritation or bruising
- Protect the skin from long‑term sensitivity
- Improve overall comfort during treatment
- Prevent lumps, bumps, or hard patches under the skin
Many people find that developing a routine and rotating injection sites not only protects their skin but also gives them a sense of confidence and control over their progress. It also feeds into the general routine-setting that comes with a weight loss program. Regimented injections, meal times and exercise are all the kinds of things that benefit sustainable progress. Remember, it’s a powerful medication; not something that you should be sticking in your body haphazardly.
Where to inject Wegovy?
Your Wegovy pen can be used in three main injection areas. Each site offers its own benefits, and this expanded guide will help you make the most of each one.
Abdomen
The abdomen is usually the easiest and most reliable injection site. It offers a broad, stable surface with ample subcutaneous fat, is easily accessible, and is ideal for comfortable, consistent injections, regardless of your physical condition. Finally, a good use for that stubborn belly fat!
Benefits of abdominal injections include:
- Clear visibility from standing or seated
- Easy reach from multiple angles
- Consistent fat distribution
- Reduced the likelihood of hitting a muscle
Technique tips to keep in mind can be:
- Always inject at least 5cm away from the belly button.
- Avoid injecting into areas that feel firmer, swollen, or bruised.
- If you’ve recently had surgery or have scars, choose another site.
Many people choose to make the abdomen their “primary” site, rotating around the area clockwise to keep things organised.
Thigh
The outer thigh is another excellent option, especially for individuals who prefer sitting down while completing their injection or who find the abdomen sensitive.
Some benefits of thigh injections are:
- Easy to access while sitting or standing
- Simple to monitor visually
Helpful for people who prefer more control during insertion
Technique tips to follow:
- Inject into the upper‑outer section of the thigh, as this can be too muscular.
- Avoid injecting too close to the knee or groin.
- Alternate legs weekly to keep the skin healthy.
Some people find the thigh slightly more sensitive than the abdomen, but rotating both legs (and sides of each leg) helps reduce tenderness.
Upper arm
The upper arm offers another effective site for rotating injections, but it can be harder to use solo, especially for reaching the injection site confidently. It’s an injection best applied by a helper.
Benefits of upper‑arm injections:
- Useful when rotating regularly
- Suitable for people whose thighs or abdomen become irritated
- A good alternative if you engage in sports that cause thigh bruising
Technique tips for injecting in the back of the upper include:
- Inject into the outer back part of the upper arm.
- Ideally, ask someone to assist. Most people struggle to inject this area or pinch the skin accurately by themselves.
If you do choose this site, ensure the person helping you has been shown how to inject safely.
Injection site comparison table
| Injection site | Ease of use | Tips for best results |
| Abdomen | Easiest | Avoid the navel area (belly button); rotate weekly |
| Thigh | Easy for self‑use | Alternate legs for comfort |
| Upper Arm | Needs help | Best with assistance for accuracy |
This quick comparison key can help you decide which site feels right each week, enabling you to maintain a comfortable rotation.
How to inject Wegovy | Step-by-step guide
Below is an expanded, beginner‑friendly walkthrough to help you carry out each injection safely and confidently.
Step 1. Prepare your injection
Wash your hands thoroughly and gather your supplies in a clean, well‑lit area. Inspect the pen for damage, confirm the dose and check the expiry date.
Ensure you have:
- Your Wegovy pen
- An alcohol wipe
- A sharps bin
- A clean, dry injection site
If your pen has been stored in the fridge, allow it to reach room temperature, as this makes injections a lot more comfortable. For damage and degradation, check for discolouration or cloudiness; these signs indicate the drugs have gone bad and shouldn’t be injected.
Step 2. Select your dose
Wegovy pens contain fixed doses that increase gradually over the first 16 weeks (in a process known as titration). Using the correct pen at each stage of your treatment ensures your body tolerates the medication safely.
Your prescriber will guide you through:
- When to increase your dose
- How long to remain on each stage
- What to do if you experience more potent side effects
Never switch doses without medical guidance. Some people achieve the desired effects without needing the maximum dosage, while others require it for the best outcomes.
Step 3. Choose your injection site
Identify a fresh site free from cuts, bruises, irritation or firmness. Clean the area with an alcohol wipe and allow it to air‑dry fully, as injecting into damp skin can sting.
Step 4. Check the flow
If your pen requires a flow check (spraying a tiny bit of solution into the air), follow the manufacturer’s instructions. This ensures the pen is working correctly and helps avoid wasted injections.
Step 5. Insert the needle
Pinch a fold of skin, hold the pen at a 90‑degree angle, and press the needle gently into place. Most people feel only a tiny pinch with little to no discomfort.
Step 6. Inject Your Dose
Press and hold the injection button until the indicator confirms your dose is fully delivered. Keep the needle in your skin for several seconds (7-10 is usually fine) to ensure complete absorption.
Step 7. Dispose of the pen safely
Place the used pen directly into your sharps bin. Your pharmacy, council collector or GP surgery can help you arrange safe disposal in line with UK regulations.
Step 8. After your injection
A small amount of redness or swelling is normal and usually fades quickly. Avoid rubbing or pressing on the area, as this can irritate the skin.
How to decide which site is best for you?
Choosing the best site each week becomes much easier once you understand your body’s patterns. You might stick around the abdomen, or you might benefit from a more rotational approach to injecting.
Ease of access
Pick a site you can reach easily and comfortably without twisting or straining. Otherwise, it’s wise to choose a site that someone can help you get to.
Comfort and sensitivity
If a site feels sore, swollen or bruised, choose a different area until it recovers.
Skin condition
Always examine your skin before injecting. Look for:
- Hard patches
- Discolouration
- Bumps
- Rashes or broken skin
Rotation
A rotation schedule prevents overuse of one area and ensures consistent absorption. Many people follow a repeating four‑week cycle to stay organised.
What to know about the possible side effects of Wegovy
Side effects are common, especially during dose increases. Understanding them helps you manage your journey more easily and avoid feeling distressed when you don’t feel completely normal.
Common side effects
- Nausea
- Vomiting
- Bloating
- Constipation or diarrhoea
- Fatigue
- Mild headaches
- Injection‑site redness or itching
How to manage side effects
- Eat bland, smaller meals
- Avoid greasy or spicy foods
- Drink plenty of water
- Don’t lie down immediately after eating
- Slow down dose increases if advised by your clinician
Less Common but Serious Effects
Seek medical advice if you experience:
- Severe stomach pain
- Persistent vomiting
- Signs of dehydration
- Difficulty breathing
When you should visit a healthcare professional
Contact your GP, weight‑management clinic, or pharmacist if:
- You experience strong or persistent side effects
- You feel unsure about your injection technique
- You notice a lump that doesn’t fade
- You think you may have injected incorrectly
For severe allergic reactions (such as anaphylaxis or immediate, painful rashing), call 999 immediately.
Conclusion
Learning how to inject Wegovy properly is a crucial part of your treatment journey. With the right technique, consistent rotation and a little confidence, each weekly dose becomes quicker, easier and more comfortable. This expanded guide ensures you fully understand the process, feel prepared each week, and know when to seek help if something doesn’t feel right.
Your clinician, pharmacist or weight‑loss specialist is always available to support you, so never hesitate to reach out if you’re feeling a little unsure. For more information on Wegovy, alternative treatments, and weight-loss journeys in general, visit The Virtual Slimming Clinic. We are not just licensed prescribers of weight-loss therapies; we also offer an extensive resource bank with documents like this to help you feel confident throughout your weight-loss journey.
Frequently Asked Questions (FAQs)
How do I select the best injection site each time?
Choose a site that feels comfortable, is easy to reach, and is free from irritation. Rotate weekly.
Can I inject Wegovy into my upper arm by myself?
Generally, no. Most people need assistance to use this site safely.
Why is rotating injection sites important?
Rotation prevents hard lumps, bruising, and skin irritation while ensuring even medication absorption.
What should I do if I miss a dose of Wegovy?
If it’s been less than 5 days, take it when you remember. If more than 5 days have passed, skip the missed dose and resume your schedule.
What should I do if I experience an allergic reaction to Wegovy?
Stop using the medication and seek medical help immediately. Call 999 for severe symptoms such as swelling or breathing difficulty.
