Quick answer: Yes, Wegovy must be refrigerated between 2°C and 8°C to maintain its strength and stability. Leaving it out for too long or exposing it to extreme temperatures can make it less effective and potentially unsafe to use.
What Is Wegovy?
Wegovy is a once-weekly injectable medication prescribed to help people living with obesity manage their weight. It’s designed for adults with BMI-classified obesity or those who are overweight with at least one weight-related condition, such as high blood pressure, type 2 diabetes or high cholesterol (it’s worth noting that Ozempic, the same drug under a different name, is generally the prescribed drug for people with diabetes). Its active ingredient, semaglutide, is part of a class of medications called GLP-1 receptor agonists that mimic the naturally occurring hormone GLP-1 (glucagon-like peptide-1). This hormone regulates appetite, slows digestion and signals your brain that you’re full after eating.
In clinical trials, Wegovy showed remarkable results. Many participants experienced significant, sustained weight loss when used alongside a healthy diet and exercise. However, Wegovy’s success doesn’t rely solely on dosage and adherence. It’s a sensitive medication that requires conscious storage to keep it safe and effective. It’s made of fragile biological molecules, so the environment you store it in directly affects its potency.
Peptide-based medications like semaglutide are highly sensitive to environmental factors such as temperature, humidity and light. It needs to be treated similarly to fresh produce. It might look fine after sitting out for a while, but its nutritional quality (or, in this case, its therapeutic value) declines over time. That’s why proper storage isn’t optional; it’s essential for safety and efficacy.
Why proper storage is important
When you pick up Wegovy from the pharmacy, it’s handed to you cold for a reason. The medication inside the pens that you inject yourself with is delicate and complex. Temperature fluctuations can easily alter its molecular structure. Improper storage doesn’t just mean a shorter shelf life; it puts your treatment (and possibly your health) at risk.
If Wegovy is stored outside its safe range, semaglutide molecules start to break down. This breakdown isn’t visible to the naked eye; the solution may still look clear, but chemically, it’s no longer stable. Using degraded medication means your body might not respond as expected, and you could see slower or inconsistent results. It could even make you poorly if it’s gone particularly badly.
Below, we’ve provided a breakdown of how temperature affects Wegovy’s stability.
| Storage condition | Temperature range | Effect on Wegovy |
| Refrigerated (ideal) | 2°C–8°C | Maintains full potency and stability |
| Room temperature (once opened) | 30°C | Stable for up to 6 weeks |
| Hot environments | Above 30°C | Rapid degradation and reduced effectiveness |
| Frozen | Below 0°C | Irreversible damage to active ingredient |
Proper storage ensures each injection delivers the intended dose of semaglutide, keeping your progress on track. As you can see, you can keep Wegovy for up to 6 weeks at room temperature, but this is only a short-term solution and is best avoided.
Does Wegovy really need to be refrigerated?
Yes, absolutely. Wegovy is a temperature-sensitive biological medication that must be kept cold to preserve its structure and therapeutic effect. Without refrigeration, the peptide bonds in semaglutide begin to break down, reducing its ability to trigger the GLP-1 receptors in your body.
Recommended storage temperature
According to EMC, Wegovy should be stored in a refrigerator at 2°C to 8°C before opening, in its original carton to protect it from light. However, once removed from the fridge, you can keep the pen for 6 weeks when stored at room temperature (below 30°C) or in a refrigerator (2°C to 8°C) away from the cooling element. This can be helpful when staggering doses and saving fridge space, but it needs to be practised with care. After that, any unused medication should be discarded.
It’s important to note that once you’ve stored a pen at room temperature, do not return it to the refrigerator. Temperature cycling-the repeated cooling and warming-can cause condensation and compromise the drug’s structure.
Why refrigeration is required
Refrigeration preserves Wegovy’s peptide molecules in their active form. When semaglutide is kept cold, its structure remains stable and the medication maintains full potency. Heat, on the other hand, speeds up degradation, which means the medication will lose its ability to suppress appetite and regulate glucose levels effectively.
In short, refrigeration keeps Wegovy “asleep” and potent until you’re ready to use it, ensuring it performs as your doctor prescribed.
How long can Wegovy stay out of the fridge?
If you accidentally leave your Wegovy pen out at room temperature, don’t panic – there is a short window of flexibility. The manufacturer states that Wegovy is stable for up to 6 weeks at room temperature, provided it remains below 30°C.
However, context matters. “Room temperature” can mean different things to different people, and, of course, depending on where you are. A cool, air-conditioned home is fine, but a bathroom counter or car glove box on a warm day is not. High heat or prolonged exposure to sunlight can quickly exceed the safe range.
If your pen was left out overnight in a warm room, check for warning signs, such as cloudiness, discolouration or condensation. If in doubt, it’s safest to replace it. It might be frustrating and expensive, but the risk of injecting a compromised medication isn’t worth it.
Can you inject Wegovy cold?
Yes, but it’s often more comfortable if you let the pen warm slightly before injecting. Injecting a cold dose of any drug is likely to cause mild stinging or irritation at the injection site. To minimise this, remove the pen from the fridge and allow it to sit at room temperature for 10 to 15 minutes before use – almost like tempering a steak before it hits the pan!
Avoid shortcuts like microwaving, running the pen under warm water or using heating pads. These methods can destroy the medication in seconds. Patience is key when letting the drug naturally reach room temperature.
How to store Wegovy to maintain its potency
The simplest rule to preserve your Wegovy is to keep it cold and keep it consistent. Wegovy is best stored in stable conditions away from heat sources, direct sunlight and moisture.
In the fridge
- Temperature. Maintain between 2°C and 8°C.
- Packaging. Keep pens in their original box to block light exposure.
- Placement. Store in the middle section of your fridge, not the door, as the door experiences more temperature fluctuations.
- Avoid freezing. Never place pens near the freezer or back wall – even partial freezing can ruin the medication when defrosting.
At room temperature
If you’re using a pen regularly and prefer room temperature storage for convenience, there are some principles to follow during the safe window.
- Keep it in a cool, dark drawer or cabinet.
- Ensure the temperature never exceeds 30°C.
- Mark your calendar or set a reminder for the 6-week expiration window.
How to store Wegovy during travel
Travelling with Wegovy can be perfectly easy and safe if you plan ahead. As you know, it has to stay in a narrow temperature range, so you’ll need a reliable way to keep it cool on the move. If it’s been opened, you can travel with it at room temperature (below 30°C). However, if it’s been unopened, then it will need to be refrigerated (between 2°C and 8°C) during travel.
For short trips:
- Use an insulated medication travel case with gel or ice packs.
- Make sure the pen isn’t in direct contact with frozen packs.
- Keep the case in your carry-on bag, never in checked luggage, where temperatures can vary dramatically.
For longer trips:
- Choose a portable medical cooler with a built-in temperature display.
- Rechargeable or USB-powered models can keep medications cool for 24–48 hours.
Once you arrive, place Wegovy in a regular refrigerator as soon as possible.
Bonus tip. If you’re travelling internationally, research your airline and the destination country’s medication policies in advance. Always carry your prescription or a doctor’s note to avoid issues at airport security.
What happens if Wegovy is stored incorrectly?
When Wegovy is stored improperly, meaning it’s been exposed to high heat, freezing, or bright sunlight, the active ingredient, semaglutide, begins to degrade. This degradation isn’t reversible and directly impacts the medication’s ability to work. It can also make the medication less safe to put in your body, although this isn’t that common.
Effects of improper storage
- Reduced potency. The most common consequence. You may notice your appetite isn’t as controlled, or your weight loss slows.
- Wasted medication. Once compromised, Wegovy cannot be restored.
- Potential irritation. Though rare, degraded medication may cause increased injection-site sensitivity.
Signs that Wegovy has gone bad
Before every injection, inspect your pen carefully.
- The solution should be clear, colourless and particle-free. If you notice cloudiness, discolouration or floating particles, do not use it.
- Check for cracks or leaks in the pen body.
- Review the expiration date printed on the box and pen label.
If anything seems off, discard the pen safely using a sharps container and contact your pharmacy for guidance. Remember, these are just the visible signs that Wegovy has gone bad – improper storage can still cause degradation you may not be able to see.
The science behind refrigeration
Refrigeration slows down molecular movement within semaglutide, preserving its structure and biological activity. At higher temperatures, these molecules begin to unfold or “denature,” similar to how heat changes an egg’s structure during the cooking process.
Once this process begins, the medication can’t be restored to its original form. No amount of cooling will bring spoiled Wegovy back to life. This is why even brief exposure to extreme heat can permanently damage Wegovy.
For perspective, stability tests conducted by pharmaceutical companies often simulate various environmental conditions. Wegovy’s formulation has been proven stable within the 36°F–46°F range for its whole shelf life, and up to 6 weeks at room temperature. Beyond that, the risk of degradation rises sharply.
Understanding Wegovy with The Virtual Slimming Clinic
Wegovy is one of the most effective medications for sustainable weight management, but it’s also one of the most temperature-sensitive. Storing it correctly, between 2°C to 8°C, ensures that every injection delivers the intended benefit.
While it can safely remain at room temperature for up to 6 weeks, refrigeration remains the gold standard for maintaining stability. Always inspect your pen before use, avoid freezing, and handle it with care during travel.
If you’re interested in using Wegovy or other similar medications in your weight loss journey, contact The Virtual Slimming Clinic today. We prescribed Wegovy, along with offering a wealth of free resources for guiding your medication plan, diet, and so much more. From storage to start-up, we have all the answers.
Frequently Asked Questions
What should I do if I forgot to refrigerate Wegovy?
If it’s been left out but kept below 30°C for less than 6 weeks, it’s still safe to use. If you’re unsure how long it was exposed or suspect it got too warm, err on the side of caution and discard it.
Can Wegovy Freeze?
No, Wegovy should never be frozen. Freezing breaks down semaglutide’s molecular structure, permanently damaging the drug. If frozen, discard the pen immediately.
How do I travel with Wegovy?
Carry Wegovy in an insulated case with cooling packs, and keep it in your hand luggage. Use a small thermometer to monitor temperature during long trips.
How long does Wegovy last in the fridge?
When refrigerated properly, Wegovy remains effective until its printed expiration date. Once removed, it’s suitable for up to 6 weeks at room temperature.
Can I store Wegovy at room temperature after opening?
Yes, Wegovy can be stored at room temperature (below 30°C) for up to 6 weeks after opening. However, once it’s been stored this way, don’t return it to the refrigerator.
